Theory and applications of NMR-based screening in pharmaceutical research.

نویسندگان

Christopher A Lepre

Jonathan M Moore

Jeffrey W Peng

چکیده

3.1. Fast Exchange Approximation 3645 4. Ligand-Based versus Receptor-Based Screening 3646 5. Ligand-Based NMR Screening Methods 3646 5.1. Transverse Relaxation Rates 3647 5.2. Longitudinal Relaxation Rates 3649 5.3. Paramagnetic Relaxation Enhancements 3649 5.4. 19F Relaxation 3650 5.5. Saturation Transfer Difference (STD) Methods 3650 5.6. WaterLOGSY 3653 5.7. Exchange-Transferred NOE 3656 5.8. Competition Binding Experiments 3656 5.9. Troubleshooting Common Problems: Aggregation and Nonspecific Binding 3657

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